What is ischemic gangrene primarily caused by?

Ischemic gangrene occurs primarily due to a lack of sufficient blood supply to a particular area of the body. This condition results from an inadequate blood flow, which can arise from various factors such as arterial blockage, severe injury, or systemic diseases that impair circulation. When blood supply is compromised, the oxygen and nutrients that are vital for cellular survival are not delivered, leading to cell death. This process can result in tissue necrosis, which is a hallmark of gangrene.

Understanding this concept helps clarify the importance of maintaining adequate blood circulation to prevent ischemic conditions. While tissue necrosis is an outcome of ischemic gangrene, it is the initial causative factor—the insufficient blood supply—that triggers the chain of events leading to tissue death.